PREVELLE Silk is a colorless hyaluronic acid gel that contains a small quantity of a local anesthetic (lidocaine) to provide pain relief at the injection site. Hyaluronic acid is a natural substance found in the human body, which moisturizes (hydrates) and cushions the skin. PREVELLE Silk is naturally broken down by your body over time. Skin testing is not required.

PREVELLE Silk is injected into facial skin, using a very fine needle, for correction of moderate to severe wrinkles and folds (e.g. areas around the nose and the mouth). The gel plumps the skin to smooth away wrinkles and folds. Your healthcare professional will work with you to develop a treatment program to meet your individual needs.

Your healthcare professional will determine if there is any reason why you are not an appropriate candidate for PREVELLE Silk. You should be aware that PREVELLE Silk:

• Should not be used in patients with a history of allergies to lidocaine or gram positive bacterial proteins.
• Should not be used in patients with a history of rare, potentially life-threatening allergic reactions or multiple severe allergies.

The product is safe for most patients. However, patients with certain conditions or allergies should not use this product. Your healthcare professional will ask you about your medical history to determine whether PREVELLE Silk is right for you.

In general, patients may experience varying levels of discomfort. However, PREVELLE Silk contains lidocaine that helps reduce injection site pain. In a clinical study, 87% of patients experienced significant pain relief at the time of injection with PREVELLE Silk. Your healthcare professional may choose additional anesthetic to further minimize discomfort.

PREVELLE Silk was studied in 45 patients who were injected with PREVELLE Silk on one side of the face and Captique, another hyaluronic dermal filler, on the other side of the face. Local symptoms were reported in diaries for 14 days by the study patients. Most symptoms were mild and went away within 3 days. In the clinical study, 69% (29) of the 42 patients who responded to the questionnaire preferred treatment with PREVELLE Silk over Captique. Of these 29 patients, 97% (28) preferred PREVELLE Silk because it was less painful.

You should ask your physician as to when make up can be applied.

After the initial injection an additional treatment, or touch up, may be needed 1 to 2 weeks later to achieve the desired level of correction. Over time PREVELLE Silk will be broken down naturally by your body, which is why you may want repeat treatments. In general, repeat treatments are needed within 3 to 6 months to maintain the desired result, but the timing of additional treatment varies from person to person.